Humanized Mouse Models of Systemic Lupus Erythematosus: Opportunities and Challenges

Animal models have played a crucial role in the understanding of the mechanisms and treatments of human diseases; however, owing to the large differences in genetic background and disease-specific characteristics, animal models cannot fully simulate the occurrence and progression of human diseases....

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Bibliographic Details
Main Authors: Jiaxuan Chen, Shuzhen Liao, Huimin Zhou, Lawei Yang, Fengbiao Guo, Shuxian Chen, Aifen Li, Quanren Pan, Chen Yang, Hua-feng Liu, Qingjun Pan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-01-01
Series:Frontiers in Immunology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.816956/full