S1PR-1/5 modulator RP-101074 shows beneficial effects in a model of central nervous system degeneration

IntroductionIn multiple sclerosis (MS), chronic disability primarily stems from axonal and neuronal degeneration, a condition resistant to conventional immunosuppressive or immunomodulatory treatments. Recent research has indicated that selective sphingosine-1-phosphate receptor S1PR-1 and -5 modula...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Mustafa Sindi, Christina Hecker, Andrea Issberner, Tobias Ruck, Sven G. Meuth, Philipp Albrecht, Michael Dietrich
Fformat: Erthygl
Iaith:English
Cyhoeddwyd: Frontiers Media S.A. 2023-08-01
Cyfres:Frontiers in Immunology
Pynciau:
Mynediad Ar-lein:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1234984/full