Triptolide mitigates the inhibition of osteogenesis induced by TNF-α in human periodontal ligament stem cells via the p-IκBα/NF-κB signaling pathway: an in-vitro study

Triptolide mitigates the inhibition of osteogenesis induced by TNF-α in human periodontal ligament stem cells via the p-IκBα/NF-κB signaling pathway: an in-vitro study

Abstract Background Triptolide is a widely utilized natural anti-inflammatory drug in clinical practice. Aim of this study was to evaluate effects of triptolide on hPDLSCs osteogenesis in an inflammatory setting and to investigate underlying mechanisms. Methods Using the tissue block method to obtai...

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Bibliographic Details
Main Authors: Hao Chen, Lina Zhang, Simeng Du, Daiwei Yang, Xiaobin Cui, Huadong Zhao, Jun Zhang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Complementary Medicine and Therapies
Subjects:
Triptolide
hPDLSCs
Osteogenesis
Periodontitis
NF-κB
Online Access:https://doi.org/10.1186/s12906-024-04408-2

Internet

https://doi.org/10.1186/s12906-024-04408-2

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