Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice

Nanoparticle-mediated selective Sfrp-1 silencing enhances bone density in osteoporotic mice

Abstract Osteoporosis (OP) is characterized by a loss in bone mass and mineral density. The stimulation of the canonical Wnt/β-catenin pathway has been reported to promote bone formation, this pathway is controlled by several regulators as secreted frizzled-related protein-1 (Sfrp-1), antagonist of...

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Autors principals:	Patricia García-García, Ricardo Reyes, Daniel García-Sánchez, Flor María Pérez-Campo, José Carlos Rodríguez-Rey, Carmen Évora, Patricia Díaz-Rodríguez, Araceli Delgado
Format:	Article
Idioma:	English
Publicat:	BMC 2022-10-01
Col·lecció:	Journal of Nanobiotechnology
Matèries:	Bone regeneration Osteoporosis Gene therapy Lipid-polymer hybrid nanoparticles
Accés en línia:	https://doi.org/10.1186/s12951-022-01674-5

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