Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal

Introduction: In Bipolar disorder the mood of the patients fluctuates between depression and mania. The main objective of the study was to find out the commonest mood stabilizers used for the treatment of Bipolar affective disorders in Western Nepal in hospitalized patients in an actual clinical...

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Main Authors: Indrajit Banerjee, Brijesh Sathian, Prasanta Kumar Chakraborty, Indraneel Banerjee, Bedanta Roy, Akhilesh Chandra Jauhari, Archana Saha
Format: Article
Language:English
Published: JCDR Research and Publications Private Limited 2014-06-01
Series:Journal of Clinical and Diagnostic Research
Subjects:
Online Access:https://jcdr.net/articles/PDF/4524/8661_CE[Ra1]_F(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf
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author Indrajit Banerjee
Brijesh Sathian
Prasanta Kumar Chakraborty
Indraneel Banerjee
Bedanta Roy
Akhilesh Chandra Jauhari
Archana Saha
author_facet Indrajit Banerjee
Brijesh Sathian
Prasanta Kumar Chakraborty
Indraneel Banerjee
Bedanta Roy
Akhilesh Chandra Jauhari
Archana Saha
author_sort Indrajit Banerjee
collection DOAJ
description Introduction: In Bipolar disorder the mood of the patients fluctuates between depression and mania. The main objective of the study was to find out the commonest mood stabilizers used for the treatment of Bipolar affective disorders in Western Nepal in hospitalized patients in an actual clinical set up. Methods: This was a cross-sectional study which was conducted between October 2009 and September 2010 at Psychiatric ward at Manipal teaching hospital, Pokhara, Nepal, a tertiary care hospital situated in Western Nepal. The diagnosis of the disease was based on ICD-10 (Tenth revision) Classification of mental and Behavioural disorders, Diagnostic Criteria for Research. We calculated odds ratio and their 95% confidence intervals (95% CI). p< 0.05 was considered as statistically significant. Results: 62.1% of the patients were less than 40 yrs, 56.3% were male, 72.4% were unemployed and 75.9% of the patients were having monthly income <10,000/month. As far as ethnicity is concerned 37.9% of the cases were Brahmin and by occupation 29.9% of the patients were students followed by housewife 25.3%, labour 17.2%, retired 13.8% respectively. Drugs and Psychotherapy [OR 1.4, 95% (CI 0.575, 3.4017)] was prescribed in age <40 years as compared to age>40 yrs. Male patients [OR 7.22, 95% (CI 0.862, 60.499)] and [OR 2.353, 95% (CI 0.857, 6.455)] received drugs by trade names and drugs not from the national drug list of Nepal as compared to females. Monthly income <10,000/month and [OR 2.8, 95% (CI 0.742, 10.56)] tendency of receiving drugs by trade names. Among the mood elevators Sodium valproate was the commonest drug to be prescribed in 51/87(58.6%) patients followed by Lithium in 30/87 (34.5%) cases and Carbamazepine in 6/87 (6.9%) cases. Sodium valproate was prescribed at 1,000 mg/day, Lithium was prescribed at 900 mg/day in and Carbamazepine was prescribed at 800 mg/day. Conclusion: Among all the mood elevators Sodium valproate is the commonest drug prescribed for the treatment of bipolar affective disorder, recommended that there is a trend of using newer drugs like sodium valproate rather than the conventional mood stabilizers like Lithium for bipolar affective disorder in Western Development region of Nepal.
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spelling doaj.art-9bfdb714e5224b41a35d3253b7f919a12022-12-22T01:18:47ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2014-06-0186HC22HC2710.7860/JCDR/2014/8661.4524Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of NepalIndrajit Banerjee0Brijesh Sathian1Prasanta Kumar Chakraborty2Indraneel Banerjee3Bedanta Roy4Akhilesh Chandra Jauhari5Archana Saha6Lecturer, Department of Pharmacology, Manipal College of Medical Sciences, Pokhara, Nepal.Assistant Professor, Department of Community Medicine, Manipal College of Medical Sciences, Pokhara, Nepal. Professor, Department of Psychiatry, Manipal Teaching Hospital, Pokhara, Nepal.Post Doctorate Trainee, Department of Urology, SMS Medical College Jaipur, Rajasthan, India.Assistant Professor, Department of Physiology, Manipal College of Medical Sciences, Pokhara, Nepal.Professor, Department of Pharmacology, Manipal College of Medical Sciences, Pokhara, Nepal.Professor and Head of the Department of Pharmacology, Manipal College of Medical Sciences, Pokhara, Nepal.Introduction: In Bipolar disorder the mood of the patients fluctuates between depression and mania. The main objective of the study was to find out the commonest mood stabilizers used for the treatment of Bipolar affective disorders in Western Nepal in hospitalized patients in an actual clinical set up. Methods: This was a cross-sectional study which was conducted between October 2009 and September 2010 at Psychiatric ward at Manipal teaching hospital, Pokhara, Nepal, a tertiary care hospital situated in Western Nepal. The diagnosis of the disease was based on ICD-10 (Tenth revision) Classification of mental and Behavioural disorders, Diagnostic Criteria for Research. We calculated odds ratio and their 95% confidence intervals (95% CI). p< 0.05 was considered as statistically significant. Results: 62.1% of the patients were less than 40 yrs, 56.3% were male, 72.4% were unemployed and 75.9% of the patients were having monthly income <10,000/month. As far as ethnicity is concerned 37.9% of the cases were Brahmin and by occupation 29.9% of the patients were students followed by housewife 25.3%, labour 17.2%, retired 13.8% respectively. Drugs and Psychotherapy [OR 1.4, 95% (CI 0.575, 3.4017)] was prescribed in age <40 years as compared to age>40 yrs. Male patients [OR 7.22, 95% (CI 0.862, 60.499)] and [OR 2.353, 95% (CI 0.857, 6.455)] received drugs by trade names and drugs not from the national drug list of Nepal as compared to females. Monthly income <10,000/month and [OR 2.8, 95% (CI 0.742, 10.56)] tendency of receiving drugs by trade names. Among the mood elevators Sodium valproate was the commonest drug to be prescribed in 51/87(58.6%) patients followed by Lithium in 30/87 (34.5%) cases and Carbamazepine in 6/87 (6.9%) cases. Sodium valproate was prescribed at 1,000 mg/day, Lithium was prescribed at 900 mg/day in and Carbamazepine was prescribed at 800 mg/day. Conclusion: Among all the mood elevators Sodium valproate is the commonest drug prescribed for the treatment of bipolar affective disorder, recommended that there is a trend of using newer drugs like sodium valproate rather than the conventional mood stabilizers like Lithium for bipolar affective disorder in Western Development region of Nepal.https://jcdr.net/articles/PDF/4524/8661_CE[Ra1]_F(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdfbipolar disorderdepressionmaniamood stabilizerspharmacotherapy
spellingShingle Indrajit Banerjee
Brijesh Sathian
Prasanta Kumar Chakraborty
Indraneel Banerjee
Bedanta Roy
Akhilesh Chandra Jauhari
Archana Saha
Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
Journal of Clinical and Diagnostic Research
bipolar disorder
depression
mania
mood stabilizers
pharmacotherapy
title Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
title_full Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
title_fullStr Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
title_full_unstemmed Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
title_short Pharmacotherapy of Bipolar Affective Disorder: A Hospital based Study from Sub Himalayan Valley of Nepal
title_sort pharmacotherapy of bipolar affective disorder a hospital based study from sub himalayan valley of nepal
topic bipolar disorder
depression
mania
mood stabilizers
pharmacotherapy
url https://jcdr.net/articles/PDF/4524/8661_CE[Ra1]_F(DK)_PF1(PAK)_PFA(AK)_PF2(AGAK)_PF2(PN).pdf
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