Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes, known as ‘basal-like’ and ‘classical...

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Bibliographic Details
Main Authors: Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Cancer & Metabolism
Subjects:
PDAC
Organoids
PDAC tumor subtype
Glycolysis
OXPHOS
MPC1
Online Access:https://doi.org/10.1186/s40170-024-00357-z

Internet

https://doi.org/10.1186/s40170-024-00357-z

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