Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Pancreatic cancer tumor organoids exhibit subtype-specific differences in metabolic profiles

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive disease characterized by complex metabolic rewiring that enables growth in changing nutrient availability and oxygen conditions. Transcriptome-based prognostic PDAC tumor subtypes, known as ‘basal-like’ and ‘classical...

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Detalhes bibliográficos
Main Authors: Hassan A. Ali, Joanna M. Karasinska, James T. Topham, Danisha Johal, Steve Kalloger, Andrew Metcalfe, Cassia S. Warren, Anthony Miyagi, Lan V. Tao, Maya Kevorkova, Shawn C. Chafe, Paul C. McDonald, Shoukat Dedhar, Seth J. Parker, Daniel J. Renouf, David F. Schaeffer
Formato: Artigo
Idioma:English
Publicado em: BMC 2024-10-01
Colecção:Cancer & Metabolism
Assuntos:
PDAC
Organoids
PDAC tumor subtype
Glycolysis
OXPHOS
MPC1
Acesso em linha:https://doi.org/10.1186/s40170-024-00357-z

Internet

https://doi.org/10.1186/s40170-024-00357-z

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