Hyperinsulinemia impairs the metabolic switch to ketone body utilization in proximal renal tubular epithelial cells under energy crisis via the inhibition of the SIRT3/SMCT1 pathway
ObjectiveTo investigate the effects and mechanism of hyperinsulinemia on the metabolic switch to β‐hydroxybutyrate (BHB) absorption and utilization under a starvation or hypoxic environment in proximal tubular epithelial cells.MethodsA high-fat diet-induced hyperinsulinemia model in ZDF rats was use...
| Автори: | , , , , , , , |
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| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
Frontiers Media S.A.
2022-09-01
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| Серія: | Frontiers in Endocrinology |
| Предмети: | |
| Онлайн доступ: | https://www.frontiersin.org/articles/10.3389/fendo.2022.960835/full |