PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION
Immunological allograft rejection is based on the process of recognition of donor antigens by T-cell receptors. Antigens are generally represented by molecules of major hystocompatibility complex (MHC), expressed by the donor organ tissue cells. Immune response to allogeneic transplant in its activi...
Main Authors: | , |
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Format: | Article |
Language: | Russian |
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Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov
2016-01-01
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Series: | Vestnik Transplantologii i Iskusstvennyh Organov |
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Online Access: | https://journal.transpl.ru/vtio/article/view/597 |
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author | A. S. Berkos G. V. Nikolaev |
author_facet | A. S. Berkos G. V. Nikolaev |
author_sort | A. S. Berkos |
collection | DOAJ |
description | Immunological allograft rejection is based on the process of recognition of donor antigens by T-cell receptors. Antigens are generally represented by molecules of major hystocompatibility complex (MHC), expressed by the donor organ tissue cells. Immune response to allogeneic transplant in its activity is greatly higher than response to conventional infection wherein the basic mechanisms of recognition of infectious antigens and alloantigens seem to be similar. In this review we have analyzed three main pathways of recognition of alloantigens. Those pathways are differentiated by the nature of antigen presenting cells, kinetics and duration of its influence on the formation of alloimmunity: direct, indirect and semidirect. Establishing the relationship between mechanisms of allorecognition and manifestations of graft rejection is of great clinical importance. |
first_indexed | 2024-04-10T00:53:15Z |
format | Article |
id | doaj.art-a71cc836a25f4edeafeaeca5f064df8f |
institution | Directory Open Access Journal |
issn | 1995-1191 |
language | Russian |
last_indexed | 2024-04-10T00:53:15Z |
publishDate | 2016-01-01 |
publisher | Federal Research Center of Transplantology and Artificial Organs named after V.I.Shumakov |
record_format | Article |
series | Vestnik Transplantologii i Iskusstvennyh Organov |
spelling | doaj.art-a71cc836a25f4edeafeaeca5f064df8f2023-03-13T10:37:23ZrusFederal Research Center of Transplantology and Artificial Organs named after V.I.ShumakovVestnik Transplantologii i Iskusstvennyh Organov1995-11912016-01-0117410411710.15825/1995-1191-2015-4-104-117512PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATIONA. S. Berkos0G. V. Nikolaev1Russian Research Institute of Hematology and Transfusiology, Saint Petersburg, Russian FederationFederal State Institution «Federal North-West Medical Research Centre» of the Ministry of Healthcare of the Russian Federation, Saint Petersburg, Russian FederationImmunological allograft rejection is based on the process of recognition of donor antigens by T-cell receptors. Antigens are generally represented by molecules of major hystocompatibility complex (MHC), expressed by the donor organ tissue cells. Immune response to allogeneic transplant in its activity is greatly higher than response to conventional infection wherein the basic mechanisms of recognition of infectious antigens and alloantigens seem to be similar. In this review we have analyzed three main pathways of recognition of alloantigens. Those pathways are differentiated by the nature of antigen presenting cells, kinetics and duration of its influence on the formation of alloimmunity: direct, indirect and semidirect. Establishing the relationship between mechanisms of allorecognition and manifestations of graft rejection is of great clinical importance.https://journal.transpl.ru/vtio/article/view/597allograftallorecognitionmajor histocompatibility complexantigen presenting cellst-cell receptor |
spellingShingle | A. S. Berkos G. V. Nikolaev PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION Vestnik Transplantologii i Iskusstvennyh Organov allograft allorecognition major histocompatibility complex antigen presenting cells t-cell receptor |
title | PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION |
title_full | PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION |
title_fullStr | PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION |
title_full_unstemmed | PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION |
title_short | PATHWAYS OF RECOGNITION OF FOREIGN ANTIGENS IN THE ADAPTIVE IMMUNE RESPONSE TO ALLOGENEIC ORGAN TRANSPLANTATION |
title_sort | pathways of recognition of foreign antigens in the adaptive immune response to allogeneic organ transplantation |
topic | allograft allorecognition major histocompatibility complex antigen presenting cells t-cell receptor |
url | https://journal.transpl.ru/vtio/article/view/597 |
work_keys_str_mv | AT asberkos pathwaysofrecognitionofforeignantigensintheadaptiveimmuneresponsetoallogeneicorgantransplantation AT gvnikolaev pathwaysofrecognitionofforeignantigensintheadaptiveimmuneresponsetoallogeneicorgantransplantation |