Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages

Accelerated cystogenesis by dietary protein load is dependent on, but not initiated by kidney macrophages

BackgroundDisease severity of autosomal dominant polycystic kidney disease (ADPKD) is influenced by diet. Dietary protein, a recognized cyst-accelerating factor, is catabolized into amino acids (AA) and delivered to the kidney leading to renal hypertrophy. Injury-induced hypertrophic signaling in AD...

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Detalhes bibliográficos
Main Authors: Randee Sedaka, Jifeng Huang, Shinobu Yamaguchi, Caleb Lovelady, Jung-Shan Hsu, Sejal Shinde, Malgorzata Kasztan, David K. Crossman, Takamitsu Saigusa
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2023-07-01
Colecção:Frontiers in Medicine
Assuntos:
polycystic kidney disease
high protein
glutamine
renal hypertophy
macrophage
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fmed.2023.1173674/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1173674/full

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