Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate
Aim :To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Materials and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily o...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Veterinary World
2013-05-01
|
| Series: | Veterinary World |
| Subjects: | |
| Online Access: | http://www.veterinaryworld.org/Vol.6/August - 2013/Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate.pdf |
| _version_ | 1831669650163761152 |
|---|---|
| author | Waseem Hussain Raja Fayaz Ahmad Zargar Naseer Ahmad Baba Parveez Ahmad Para Mudasir Sultana Hina Ashraf Waiz Nisar Ahmad Nisar |
| author_facet | Waseem Hussain Raja Fayaz Ahmad Zargar Naseer Ahmad Baba Parveez Ahmad Para Mudasir Sultana Hina Ashraf Waiz Nisar Ahmad Nisar |
| author_sort | Waseem Hussain Raja |
| collection | DOAJ |
| description | Aim :To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Materials and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily oral treatment regimes for 98 days. Group I served as control receiving only corn oil, group II received th chlorpyriphos @ 5.5 mg/ kg in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IV th received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water. Group V received th vitamin C @ 100mg/kg in water, group VI received a combination of chlorpyriphos @ 5.5mg/kg and vitamin C @ th th 100mg/kg , group VII received lead acetate @ 100 ppm in water and vitamin C @ 100mg/kg and group VIII received chlorpyriphos @ 5.5mg/kg , lead acetate @100ppm in water and vitamin C @ 100mg/kg. Results: Administration of both chlorpyriphos and lead acetate caused a significant decrease in oxidative stress parameters viz. blood glutathione, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) along with a significant increase in lipid peroxidation level when given alone or in combination. Conclusions: The study demonstrated that treatment of chlorpyriphos and lead treated rats with vitamin C significantly improved some of altered oxidative stress parameters revealing the protective effect of this vitamin C against oxidative stress induced by chlorpyriphos and lead. [Vet World 2013; 6(8.000): 461-466] |
| first_indexed | 2024-12-19T23:03:18Z |
| format | Article |
| id | doaj.art-a899275ca2f640d990fc9643d3c13bbf |
| institution | Directory Open Access Journal |
| issn | 0972-8988 2231-0916 |
| language | English |
| last_indexed | 2024-12-19T23:03:18Z |
| publishDate | 2013-05-01 |
| publisher | Veterinary World |
| record_format | Article |
| series | Veterinary World |
| spelling | doaj.art-a899275ca2f640d990fc9643d3c13bbf2022-12-21T20:02:27ZengVeterinary WorldVeterinary World0972-89882231-09162013-05-016846146610.5455/vetworld.2013.461-466Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetateWaseem Hussain RajaFayaz Ahmad ZargarNaseer Ahmad BabaParveez Ahmad ParaMudasir SultanaHina Ashraf WaizNisar Ahmad NisarAim :To evaluate the effects of chlorpyriphos, lead acetate, vitamin C alone, and in combination on the activity of oxidative stress parameters in wistar rats. Materials and Methods: Rats of 150-200g body weight were divided into eight groups of six animals each and were subjected to various daily oral treatment regimes for 98 days. Group I served as control receiving only corn oil, group II received th chlorpyriphos @ 5.5 mg/ kg in corn oil, group III received lead acetate @100 ppm in water, whereas animals in group IV th received a combination of chlorpyriphos @ 5.5mg/kg in corn oil and lead acetate @ 100 ppm in water. Group V received th vitamin C @ 100mg/kg in water, group VI received a combination of chlorpyriphos @ 5.5mg/kg and vitamin C @ th th 100mg/kg , group VII received lead acetate @ 100 ppm in water and vitamin C @ 100mg/kg and group VIII received chlorpyriphos @ 5.5mg/kg , lead acetate @100ppm in water and vitamin C @ 100mg/kg. Results: Administration of both chlorpyriphos and lead acetate caused a significant decrease in oxidative stress parameters viz. blood glutathione, catalase, superoxide dismutase (SOD), glutathione peroxidase (GPx), glutathione-s-transferase (GST) along with a significant increase in lipid peroxidation level when given alone or in combination. Conclusions: The study demonstrated that treatment of chlorpyriphos and lead treated rats with vitamin C significantly improved some of altered oxidative stress parameters revealing the protective effect of this vitamin C against oxidative stress induced by chlorpyriphos and lead. [Vet World 2013; 6(8.000): 461-466]http://www.veterinaryworld.org/Vol.6/August - 2013/Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate.pdfchlorpyriphoslead acetateoxidative stressvitamin C |
| spellingShingle | Waseem Hussain Raja Fayaz Ahmad Zargar Naseer Ahmad Baba Parveez Ahmad Para Mudasir Sultana Hina Ashraf Waiz Nisar Ahmad Nisar Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate Veterinary World chlorpyriphos lead acetate oxidative stress vitamin C |
| title | Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate |
| title_full | Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate |
| title_fullStr | Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate |
| title_full_unstemmed | Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate |
| title_short | Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate |
| title_sort | experimental study on the effect of vitamin c administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate |
| topic | chlorpyriphos lead acetate oxidative stress vitamin C |
| url | http://www.veterinaryworld.org/Vol.6/August - 2013/Experimental study on the effect of vitamin C administration on lipid peroxidation and antioxidant enzyme activity in rats exposed to chlorpyriphos and lead acetate.pdf |
| work_keys_str_mv | AT waseemhussainraja experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate AT fayazahmadzargar experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate AT naseerahmadbaba experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate AT parveezahmadpara experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate AT mudasirsultana experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate AT hinaashrafwaiz experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate AT nisarahmadnisar experimentalstudyontheeffectofvitamincadministrationonlipidperoxidationandantioxidantenzymeactivityinratsexposedtochlorpyriphosandleadacetate |