Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these...
| Auteurs principaux: | , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
eLife Sciences Publications Ltd
2023-04-01
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| Collection: | eLife |
| Sujets: | |
| Accès en ligne: | https://elifesciences.org/articles/83209 |