Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these...
| Автори: | , , , , , |
|---|---|
| Формат: | Стаття |
| Мова: | English |
| Опубліковано: |
eLife Sciences Publications Ltd
2023-04-01
|
| Серія: | eLife |
| Предмети: | |
| Онлайн доступ: | https://elifesciences.org/articles/83209 |