Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction

Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction

Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these...

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Bibliographic Details
Main Authors: Mingkun Wang, Belle Yanyu Lin, Shuofei Sun, Charles Dai, Feifei Long, Jonathan T Butcher
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2023-04-01
Series:eLife
Subjects:
congenital heart defect
morphogenesis
mechanobiology
maturation
biomechanics
Online Access:https://elifesciences.org/articles/83209

Internet

https://elifesciences.org/articles/83209

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