Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR
Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...
| Auteurs principaux: | , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
BMC
2019-05-01
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| Collection: | Cell Communication and Signaling |
| Sujets: | |
| Accès en ligne: | http://link.springer.com/article/10.1186/s12964-019-0354-2 |