Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR

Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...

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Chi tiết về thư mục
Những tác giả chính:	Carlo Follo, Chiara Vidoni, Federica Morani, Alessandra Ferraresi, Christian Seca, Ciro Isidoro
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	BMC 2019-05-01
Loạt:	Cell Communication and Signaling
Những chủ đề:	Autophagy Starvation mTORC1 Lysosome TFEB Protein translation
Truy cập trực tuyến:	http://link.springer.com/article/10.1186/s12964-019-0354-2

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