Amino acid response by Halofuginone in Cancer cells triggers autophagy through proteasome degradation of mTOR
Abstract Background In the event of amino acid starvation, the cell activates two main protective pathways: Amino Acid starvation Response (AAR), to inhibit global translation, and autophagy, to recover the essential substrates from degradation of redundant self-components. Whether and how AAR and a...
| Հիմնական հեղինակներ: | , , , , , |
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| Ձևաչափ: | Հոդված |
| Լեզու: | English |
| Հրապարակվել է: |
BMC
2019-05-01
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| Շարք: | Cell Communication and Signaling |
| Խորագրեր: | |
| Առցանց հասանելիություն: | http://link.springer.com/article/10.1186/s12964-019-0354-2 |