O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

O‐GlcNAc Transferase Promotes Compensated Cardiac Function and Protein Kinase A O‐GlcNAcylation During Early and Established Pathological Hypertrophy From Pressure Overload

Background Protein posttranslational modifications by O‐linked β‐N‐acetylglucosamine (O‐GlcNAc) increase with cardiac hypertrophy, yet the functional effects of these changes are incompletely understood. In other organs, O‐GlcNAc promotes adaptation to acute physiological stressors; however, prolong...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Wei‐Zhong Zhu, Danny El‐Nachef, Xiulan Yang, Dolena Ledee, Aaron K. Olson
Μορφή: Άρθρο
Γλώσσα:English
Έκδοση: Wiley 2019-06-01
Σειρά:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Θέματα:
cardiac failure
cardiac hypertrophy
O‐GlcNAc
OGT
pressure overload
protein kinase A phosphorylation
Διαθέσιμο Online:https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

Διαδίκτυο

https://www.ahajournals.org/doi/10.1161/JAHA.118.011260

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