Inhibition of Human Sulfotransferases by Phthalate Monoesters

Inhibition of Human Sulfotransferases by Phthalate Monoesters

ObjectiveThis study aimed to investigate the inhibition of human important phase II metabolic enzyme sulfotransferases (SULTs) by phthalate monoesters, which are important metabolites of phthalate esters (PAEs).MethodRecombinant SULT-catalyzed metabolism of p-nitrophenol (PNP) was employed as the pr...

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Detalhes bibliográficos
Principais autores: Hui Huang, Bei-Di Lan, Yu-Jing Zhang, Xiao-Juan Fan, Min-Cui Hu, Guo-Qiang Qin, Fei-Ge Wang, Yue Wu, Tao Zheng, Jun-Hui Liu
Formato: Artigo
Idioma:English
Publicado em: Frontiers Media S.A. 2022-04-01
coleção:Frontiers in Endocrinology
Assuntos:
phthalate esters (PAEs)
sulfotransferases (SULTs)
enzyme inhibition
in silico docking
in vitro–in vivo extrapolation
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fendo.2022.868105/full

Internet

https://www.frontiersin.org/articles/10.3389/fendo.2022.868105/full

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