Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells

Molecular underpinnings and environmental drivers of loss of heterozygosity in Drosophila intestinal stem cells

Summary: During development and aging, genome mutation leading to loss of heterozygosity (LOH) can uncover recessive phenotypes within tissue compartments. This phenomenon occurs in normal human tissues and is prevalent in pathological genetic conditions and cancers. While studies in yeast have defi...

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Bibliographic Details
Main Authors: Lara Al Zouabi, Marine Stefanutti, Spyridon Roumeliotis, Gwenn Le Meur, Benjamin Boumard, Nick Riddiford, Natalia Rubanova, Mylène Bohec, Louis Gervais, Nicolas Servant, Allison J. Bardin
Format: Article
Language:English
Published: Elsevier 2023-12-01
Series:Cell Reports
Subjects:
CP: Developmental biology
CP: Genomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723014973

Internet

http://www.sciencedirect.com/science/article/pii/S2211124723014973

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