Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor Effects

Synthesis and Biological Evaluation of Novel 2-Amino-1,4-Naphthoquinone Amide-Oxime Derivatives as Potent IDO1/STAT3 Dual Inhibitors with Prospective Antitumor Effects

Indoleamine-2,3-dioxygenase 1 (IDO1) and signal transducer and activator of transcription 3 (STAT3) have emerged as significant targets in the tumor microenvironment for cancer therapy. In this study, we synthesized three novel 2-amino-1,4-naphthoquinone amide-oxime derivatives and identified them a...

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Bibliographic Details
Main Authors: Ri-Zhen Huang, Qiao-Ling Liang, Xiao-Teng Jing, Ke Wang, Hui-Yong Zhang, Heng-Shan Wang, Xian-Li Ma, Jian-Hua Wei, Ye Zhang
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Molecules
Subjects:
indoleamine 2,3-dioxygenase 1
signal transducer and activator of transcription 3
dual inhibitors
naphthoquinone-oxime derivatives
anticancer agents
Online Access:https://www.mdpi.com/1420-3049/28/16/6135

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https://www.mdpi.com/1420-3049/28/16/6135

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