Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN

Abstract The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration. Therefore, MYCN is being pursued as an attractive therapeutic target for selective inhibitio...

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Bibliographic Details
Main Authors: Xiaoling Zhang, Xianling Cong, Xiangting Jin, Yu’e Liu, Tong Zhang, Xinyuan Fan, Xiyao Shi, Xiaoying Zhang, Xue Wang, Yong-Guang Yang, Xiangpeng Dai
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06030-5

Internet

https://doi.org/10.1038/s41419-023-06030-5

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