Deficiency of BAP1 inhibits neuroblastoma tumorigenesis through destabilization of MYCN
Abstract The transcription factor MYCN is frequently amplified and overexpressed in a variety of cancers including high-risk neuroblastoma (NB) and promotes tumor cell proliferation, survival, and migration. Therefore, MYCN is being pursued as an attractive therapeutic target for selective inhibitio...
| Auteurs principaux: | , , , , , , , , , , |
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| Format: | Article |
| Langue: | English |
| Publié: |
Nature Publishing Group
2023-08-01
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| Collection: | Cell Death and Disease |
| Accès en ligne: | https://doi.org/10.1038/s41419-023-06030-5 |