Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition

Summary: Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but are not considered canonical antigen-presenting cells, and the impact of IEC-MHC class II signaling on gut homeostasis remains enigma...

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Bibliographic Details
Main Authors: W. Zac Stephens, Jason L. Kubinak, Arevik Ghazaryan, Kaylyn M. Bauer, Rickesha Bell, Kate Buhrke, Tyson R. Chiaro, Allison M. Weis, William W. Tang, Josh K. Monts, Ray Soto, H. Atakan Ekiz, Ryan M. O’Connell, June L. Round
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Cell Reports
Subjects:
MHC class II
intestinal epithelia
antigen processing
microbiome
immunity
macrophage
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721013899

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http://www.sciencedirect.com/science/article/pii/S2211124721013899

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