The enhanced antitumor activity of bispecific antibody targeting PD-1/PD-L1 signaling

Abstract The programmed cell death 1 (PD-1) signaling pathway, a key player in immune checkpoint regulation, has become a focal point in cancer immunotherapy. In the context of cancer, upregulated PD-L1 on tumor cells can result in T cell exhaustion and immune evasion, fostering tumor progression. T...

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Bibliographic Details
Main Authors: Tianye Li, Mengke Niu, Jianwei Zhou, Kongming Wu, Ming Yi
Format: Article
Language:English
Published: BMC 2024-03-01
Series:Cell Communication and Signaling
Subjects:
Online Access:https://doi.org/10.1186/s12964-024-01562-5