Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway

Ritonavir Has Reproductive Toxicity Depending on Disrupting PI3K/PDK1/AKT Signaling Pathway

Ritonavir (RTV) is an antiviral and a component of COVID-19 treatments. Moreover, RTV demonstrates anti-cancer effects by suppressing AKT. However, RTV has cytotoxicity and suppresses sperm functions by altering AKT activity. Although abnormal AKT activity is known for causing detrimental effects on...

Full description

Bibliographic Details
Main Authors: Eun-Ju Jung, Jae-Hwan Jo, Claudine Uwamahoro, Seung-Ik Jang, Woo-Jin Lee, Ju-Mi Hwang, Jeong-Won Bae, Woo-Sung Kwon
Format: Article
Language:English
Published: MDPI AG 2024-01-01
Series:Toxics
Subjects:
ritonavir
spermatozoa
capacitation
PI3K/PDK1/AKT pathway
Online Access:https://www.mdpi.com/2305-6304/12/1/73

Internet

https://www.mdpi.com/2305-6304/12/1/73

Similar Items