Tetrandrine activates STING/TBK1/IRF3 pathway to potentiate anti-PD-1 immunotherapy efficacy in non-small cell lung cancer

The efficacy of PD-1 therapy in non-small cell lung cancer (NSCLC) patients remains unsatisfactory. Activating the STING pathway is a promising strategy to improve PD-1 inhibitor efficacy. Here, we found tetrandrine (TET), an anti-tumor compound extracted from a medicinal plant commonly used in trad...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид: Yan Tan, Qiancheng Zhu, Meilin Yang, Fan Yang, Qi Zeng, Zebo Jiang, Dan Li
Формат: Өгүүллэг
Хэл сонгох:English
Хэвлэсэн: Elsevier 2024-09-01
Цуврал:Pharmacological Research
Нөхцлүүд:
Онлайн хандалт:http://www.sciencedirect.com/science/article/pii/S1043661824002597