Efficient genome editing in Claviceps purpurea using a CRISPR/Cas9 ribonucleoprotein method

Efficient genome editing in Claviceps purpurea using a CRISPR/Cas9 ribonucleoprotein method

Claviceps purpurea produces many pharmacologically important ergot alkaloids (EAS), which are widely used to treat migraine and hypertension and to aid childbirth. Although an EAS biosynthetic cluster of C. purpurea has been discovered more than 20 years ago, the complete biosynthetic pathway of EAS...

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Bibliographic Details
Main Authors: Lu Yu, Meili Xiao, Zhihua Zhu, Yinmei Wang, Zhihua Zhou, Pingping Wang, Gen Zou
Format: Article
Language:English
Published: KeAi Communications Co., Ltd. 2022-06-01
Series:Synthetic and Systems Biotechnology
Subjects:
Ribonucleoprotein
Genome editing
Ergot alkaloids
Biosynthetic pathway
Homologous recombination
Online Access:http://www.sciencedirect.com/science/article/pii/S2405805X22000096

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http://www.sciencedirect.com/science/article/pii/S2405805X22000096

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