Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Microglia undergo sex-dimorphic transcriptional and metabolic rewiring during aging

Abstract Microglia, the brain’s resident macrophages, maintain brain homeostasis and respond to injury and infection. During aging they undergo functional changes, but the underlying mechanisms and their contributions to neuroprotection versus neurodegeneration are unclear. Previous studies suggeste...

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Bibliographic Details
Main Authors: Seokjo Kang, Emily Y. Ko, Amelia E. Andrews, Juliana E. Shin, Karina J. Nance, Pijus K. Barman, Peter S. Heeger, Willard M. Freeman, Bérénice A. Benayoun, Helen S. Goodridge
Format: Article
Language:English
Published: BMC 2024-06-01
Series:Journal of Neuroinflammation
Subjects:
Microglia
Aging
Alzheimer’s disease
Sex differences
Online Access:https://doi.org/10.1186/s12974-024-03130-7

Internet

https://doi.org/10.1186/s12974-024-03130-7

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