Antioxidant Activity of Coumarins and Their Metal Complexes
Ubiquitously present in plant life, coumarins, as a class of phenolic compounds, have multiple applications—in everyday life, in organic synthesis, in medicine and many others. Coumarins are well known for their broad spectrum of physiological effects. The specific structure of the coumarin scaffold...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-04-01
|
| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/16/5/651 |
| _version_ | 1827740433989500928 |
|---|---|
| author | Lozan Todorov Luciano Saso Irena Kostova |
| author_facet | Lozan Todorov Luciano Saso Irena Kostova |
| author_sort | Lozan Todorov |
| collection | DOAJ |
| description | Ubiquitously present in plant life, coumarins, as a class of phenolic compounds, have multiple applications—in everyday life, in organic synthesis, in medicine and many others. Coumarins are well known for their broad spectrum of physiological effects. The specific structure of the coumarin scaffold involves a conjugated system with excellent charge and electron transport properties. The antioxidant activity of natural coumarins has been a subject of intense study for at least two decades. Significant research into the antioxidant behavior of natural/semi-synthetic coumarins and their complexes has been carried out and published in scientific literature. The authors of this review have noted that, during the past five years, research efforts seem to have been focused on the synthesis and examination of synthetic coumarin derivatives with the aim to produce potential drugs with enhanced, modified or entirely novel effects. As many pathologies are associated with oxidative stress, coumarin-based compounds could be excellent candidates for novel medicinal molecules. The present review aims to inform the reader on some prominent results from investigations into the antioxidant properties of novel coumarin compounds over the past five years. |
| first_indexed | 2024-03-11T03:25:57Z |
| format | Article |
| id | doaj.art-ed06769c596e4ac495272d4a4f32ca7a |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-11T03:25:57Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-ed06769c596e4ac495272d4a4f32ca7a2023-11-18T02:48:01ZengMDPI AGPharmaceuticals1424-82472023-04-0116565110.3390/ph16050651Antioxidant Activity of Coumarins and Their Metal ComplexesLozan Todorov0Luciano Saso1Irena Kostova2Department of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, BulgariaDepartment of Physiology and Pharmacology “Vittorio Erspamer”, Faculty of Pharmacy and Medicine, Sapienza University, 00185 Rome, ItalyDepartment of Chemistry, Faculty of Pharmacy, Medical University-Sofia, 1000 Sofia, BulgariaUbiquitously present in plant life, coumarins, as a class of phenolic compounds, have multiple applications—in everyday life, in organic synthesis, in medicine and many others. Coumarins are well known for their broad spectrum of physiological effects. The specific structure of the coumarin scaffold involves a conjugated system with excellent charge and electron transport properties. The antioxidant activity of natural coumarins has been a subject of intense study for at least two decades. Significant research into the antioxidant behavior of natural/semi-synthetic coumarins and their complexes has been carried out and published in scientific literature. The authors of this review have noted that, during the past five years, research efforts seem to have been focused on the synthesis and examination of synthetic coumarin derivatives with the aim to produce potential drugs with enhanced, modified or entirely novel effects. As many pathologies are associated with oxidative stress, coumarin-based compounds could be excellent candidates for novel medicinal molecules. The present review aims to inform the reader on some prominent results from investigations into the antioxidant properties of novel coumarin compounds over the past five years.https://www.mdpi.com/1424-8247/16/5/651antioxidantcoumarinsradicals’ scavengingantioxidant assayscoordination compoundsmolecular hybrids |
| spellingShingle | Lozan Todorov Luciano Saso Irena Kostova Antioxidant Activity of Coumarins and Their Metal Complexes Pharmaceuticals antioxidant coumarins radicals’ scavenging antioxidant assays coordination compounds molecular hybrids |
| title | Antioxidant Activity of Coumarins and Their Metal Complexes |
| title_full | Antioxidant Activity of Coumarins and Their Metal Complexes |
| title_fullStr | Antioxidant Activity of Coumarins and Their Metal Complexes |
| title_full_unstemmed | Antioxidant Activity of Coumarins and Their Metal Complexes |
| title_short | Antioxidant Activity of Coumarins and Their Metal Complexes |
| title_sort | antioxidant activity of coumarins and their metal complexes |
| topic | antioxidant coumarins radicals’ scavenging antioxidant assays coordination compounds molecular hybrids |
| url | https://www.mdpi.com/1424-8247/16/5/651 |
| work_keys_str_mv | AT lozantodorov antioxidantactivityofcoumarinsandtheirmetalcomplexes AT lucianosaso antioxidantactivityofcoumarinsandtheirmetalcomplexes AT irenakostova antioxidantactivityofcoumarinsandtheirmetalcomplexes |