RT2 PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease

Abstract Amyotrophic lateral sclerosis (ALS) is a degenerative motor neuron disease that has been linked to defective DNA repair. Many familial ALS patients harbor autosomal dominant mutations in the gene encoding the RNA/DNA binding protein ‘fused in sarcoma’ (FUS) commonly inducing its cytoplasmic...

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Bibliographic Details
Main Authors: Haibo Wang, Suganya Rangaswamy, Manohar Kodavati, Joy Mitra, Wenting Guo, Erika N. Guerrero, Ludo Van Den Bosch, Muralidhar L. Hegde
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Brain
Subjects:
Online Access:https://doi.org/10.1186/s13041-019-0526-4