Structure-Based Virtual Screening of Ultra-Large Library Yields Potent Antagonists for a Lipid GPCR
Cysteinyl leukotriene G protein-coupled receptors, CysLT1R and CysLT2R, regulate bronchoconstrictive and pro-inflammatory effects and play a key role in allergic disorders, cardiovascular diseases, and cancer. CysLT1R antagonists have been widely used to treat asthma disorders, while CysLT2R is a po...
| Main Authors: | , , , , , , , , , , , , |
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| 格式: | Article |
| 語言: | English |
| 出版: |
MDPI AG
2020-12-01
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| 叢編: | Biomolecules |
| 主題: | |
| 在線閱讀: | https://www.mdpi.com/2218-273X/10/12/1634 |