Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications
Accumulating evidence indicates the occurrence and development of diabetic complications relates to not only constant high plasma glucose, but also glucose fluctuations which affect various kinds of molecular mechanisms in various target cells and tissues. In this review, we detail reactive oxygen s...
| Main Authors: | , , , , , , , , |
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| 格式: | 文件 |
| 语言: | English |
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Frontiers Media S.A.
2019-09-01
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| 丛编: | Frontiers in Endocrinology |
| 主题: | |
| 在线阅读: | https://www.frontiersin.org/article/10.3389/fendo.2019.00640/full |
| _version_ | 1828393372306374656 |
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| author | Zhen-Ye Zhang Ling-Feng Miao Ling-Ling Qian Ning Wang Miao-Miao Qi Yu-Min Zhang Shi-Peng Dang Ying Wu Ru-Xing Wang |
| author_facet | Zhen-Ye Zhang Ling-Feng Miao Ling-Ling Qian Ning Wang Miao-Miao Qi Yu-Min Zhang Shi-Peng Dang Ying Wu Ru-Xing Wang |
| author_sort | Zhen-Ye Zhang |
| collection | DOAJ |
| description | Accumulating evidence indicates the occurrence and development of diabetic complications relates to not only constant high plasma glucose, but also glucose fluctuations which affect various kinds of molecular mechanisms in various target cells and tissues. In this review, we detail reactive oxygen species and their potentially damaging effects upon glucose fluctuations and resultant downstream regulation of protein signaling pathways, including protein kinase C, protein kinase B, nuclear factor-κB, and the mitogen-activated protein kinase signaling pathway. A deeper understanding of glucose-fluctuation-related molecular mechanisms in the development of diabetic complications may enable more potential target therapies in future. |
| first_indexed | 2024-12-10T07:36:58Z |
| format | Article |
| id | doaj.art-f45107d0c81f4cb8b51a9b8315ce168b |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-10T07:36:58Z |
| publishDate | 2019-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f45107d0c81f4cb8b51a9b8315ce168b2022-12-22T01:57:24ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922019-09-011010.3389/fendo.2019.00640429352Molecular Mechanisms of Glucose Fluctuations on Diabetic ComplicationsZhen-Ye ZhangLing-Feng MiaoLing-Ling QianNing WangMiao-Miao QiYu-Min ZhangShi-Peng DangYing WuRu-Xing WangAccumulating evidence indicates the occurrence and development of diabetic complications relates to not only constant high plasma glucose, but also glucose fluctuations which affect various kinds of molecular mechanisms in various target cells and tissues. In this review, we detail reactive oxygen species and their potentially damaging effects upon glucose fluctuations and resultant downstream regulation of protein signaling pathways, including protein kinase C, protein kinase B, nuclear factor-κB, and the mitogen-activated protein kinase signaling pathway. A deeper understanding of glucose-fluctuation-related molecular mechanisms in the development of diabetic complications may enable more potential target therapies in future.https://www.frontiersin.org/article/10.3389/fendo.2019.00640/fullglucose fluctuationsdiabetesreactive oxygen speciesprotein kinase Cprotein kinase Bmitogen-activated protein kinase |
| spellingShingle | Zhen-Ye Zhang Ling-Feng Miao Ling-Ling Qian Ning Wang Miao-Miao Qi Yu-Min Zhang Shi-Peng Dang Ying Wu Ru-Xing Wang Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications Frontiers in Endocrinology glucose fluctuations diabetes reactive oxygen species protein kinase C protein kinase B mitogen-activated protein kinase |
| title | Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications |
| title_full | Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications |
| title_fullStr | Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications |
| title_full_unstemmed | Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications |
| title_short | Molecular Mechanisms of Glucose Fluctuations on Diabetic Complications |
| title_sort | molecular mechanisms of glucose fluctuations on diabetic complications |
| topic | glucose fluctuations diabetes reactive oxygen species protein kinase C protein kinase B mitogen-activated protein kinase |
| url | https://www.frontiersin.org/article/10.3389/fendo.2019.00640/full |
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