Endoplasmic reticulum-associated SKN-1A/Nrf1 mediates a cytoplasmic unfolded protein response and promotes longevity
Unfolded protein responses (UPRs) safeguard cellular function during proteotoxic stress and aging. In a previous paper (Lehrbach and Ruvkun, 2016) we showed that the ER-associated SKN-1A/Nrf1 transcription factor activates proteasome subunit expression in response to proteasome dysfunction, but it w...
Main Authors: | , |
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Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications Ltd
2019-04-01
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Series: | eLife |
Subjects: | |
Online Access: | https://elifesciences.org/articles/44425 |