Using circulating microbial cell-free DNA to identify persistent Treponema pallidum infection in serofast syphilis patients

Summary: The question of whether serofast status of syphilis patients indicates an ongoing low-grade Treponema pallidum (T. pallidum) infection remains unanswered. To address this, we developed a machine learning model to identify T. pallidum in cell-free DNA (cfDNA) using next-generation sequencing...

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Hlavní autoři: Meng Yin Wu, Lu Chen, Li Cheng Liu, Ming Juan Liu, Yan Feng Li, He Yi Zheng, Ling Leng, Yi Jun Zou, Wei Jun Chen, Jun Li
Médium: Článek
Jazyk:English
Vydáno: Elsevier 2024-04-01
Edice:iScience
Témata:
On-line přístup:http://www.sciencedirect.com/science/article/pii/S2589004224006205