Rescuing ESAT-6 Specific CD4 T Cells From Terminal Differentiation Is Critical for Long-Term Control of Murine Mtb Infection
In most cases, Mycobacterium tuberculosis (Mtb) causes life-long chronic infections, which poses unique challenges for the immune system. Most of the current tuberculosis (TB) subunit vaccines incorporate immunodominant antigens and at this point, it is poorly understood how the CD4 T cell subsets r...
Main Authors: | Helena Strand Clemmensen, Niels Peter Hell Knudsen, Rolf Billeskov, Ida Rosenkrands, Gregers Jungersen, Claus Aagaard, Peter Andersen, Rasmus Mortensen |
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Format: | Article |
Language: | English |
Published: |
Frontiers Media S.A.
2020-11-01
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Series: | Frontiers in Immunology |
Subjects: | |
Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2020.585359/full |
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