A Fungal-Selective Cytochrome bc₁ Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance
To cause disease, a microbial pathogen must adapt to the challenges of its host environment. The leading fungal pathogen Candida albicans colonizes nutrient-poor bodily niches, withstands attack from the immune system, and tolerates treatment with azole antifungals, often evolving resistance. To dis...
Main Authors: | Srinivas, Raja, Lancaster, Alex K., Scherz-Shouval, Ruth, Whitesell, Luke, Vincent, Benjamin Matteson, Langlois, Jean-Baptiste, Tidor, Bruce, Buchwald, Stephen Leffler, Lindquist, Susan |
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Other Authors: | Massachusetts Institute of Technology. Department of Biological Engineering |
Format: | Article |
Language: | en_US |
Published: |
Elsevier
2017
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Online Access: | http://hdl.handle.net/1721.1/111146 https://orcid.org/0000-0002-3320-3969 https://orcid.org/0000-0003-3875-4775 https://orcid.org/0000-0003-1307-882X |
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