Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet
Little is known about how metabolites couple tissue-specific stem cell function with physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies,...
Main Authors: | , , , , , , , , , , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
Elsevier BV
2020
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Online Access: | https://hdl.handle.net/1721.1/126800 |