Ketone Body Signaling Mediates Intestinal Stem Cell Homeostasis and Adaptation to Diet

Little is known about how metabolites couple tissue-specific stem cell function with physiology. Here we show that, in the mammalian small intestine, the expression of Hmgcs2 (3-hydroxy-3-methylglutaryl-CoA synthetase 2), the gene encoding the rate-limiting enzyme in the production of ketone bodies,...

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Bibliographic Details
Main Authors: Cheng, Chia-Wei, Gunduz, Nuray, Eng, George M, Tripathi, Surya, Calibasi Kocal, Gizem, Rickelt, Steffen, Moreno, Marta, Iqbal, Ameena M., Bauer-Rowe, Khristian E., Imada, Shinya, Ulutas, Mehmet Sefa, Mylonas, Konstantinos, Whary, Mark T., Hynes, Richard O, Boyer, Laurie Ann, Fox, James G, Regev, Aviv, Yilmaz, Omer H.
Other Authors: Massachusetts Institute of Technology. Department of Biology
Format: Article
Language:English
Published: Elsevier BV 2020
Online Access:https://hdl.handle.net/1721.1/126800