Inhibition of Hsp90 in Streptomyces coelicolor
Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2007
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| Online Access: | http://hdl.handle.net/1721.1/36280 |
| _version_ | 1826216577556545536 |
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| author | Wu, Katherine A. (Katherine Ann) |
| author2 | Sarah E. O'Connor. |
| author_facet | Sarah E. O'Connor. Wu, Katherine A. (Katherine Ann) |
| author_sort | Wu, Katherine A. (Katherine Ann) |
| collection | MIT |
| description | Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005. |
| first_indexed | 2024-09-23T16:49:30Z |
| format | Thesis |
| id | mit-1721.1/36280 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T16:49:30Z |
| publishDate | 2007 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/362802019-04-11T02:05:25Z Inhibition of Hsp90 in Streptomyces coelicolor Inhibition of Hsp90 in S. coelicolor Wu, Katherine A. (Katherine Ann) Sarah E. O'Connor. Massachusetts Institute of Technology. Dept. of Chemistry. Massachusetts Institute of Technology. Dept. of Chemistry. Chemistry. Thesis (S.B.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2005. Includes bibliographical references (leaves 20-21). Inhibition of the chaperone protein Hsp90 in plants and insects has been found to result in drastic changes in phenotype. We investigated the effect of Hsp90 inhibition on the bacteria Streptomyces coelicolor. These changes were studied by growing S. coelicolor in the presence of Hsp90 inhibitors, extracting the growth media, and subjecting the extractions to HPLC and MS analysis. It has been found that reproducibility is difficult to achieve. Since the genome of S. coelicolor has been sequenced, attention was turned to studying changes in mRNA expression levels, which gave more reproducible results, as well as insight to the specific genes being affected. by Katherine A. Wu. S.B. 2007-02-21T13:20:56Z 2007-02-21T13:20:56Z 2005 2005 Thesis http://hdl.handle.net/1721.1/36280 77529661 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 21 leaves application/pdf Massachusetts Institute of Technology |
| spellingShingle | Chemistry. Wu, Katherine A. (Katherine Ann) Inhibition of Hsp90 in Streptomyces coelicolor |
| title | Inhibition of Hsp90 in Streptomyces coelicolor |
| title_full | Inhibition of Hsp90 in Streptomyces coelicolor |
| title_fullStr | Inhibition of Hsp90 in Streptomyces coelicolor |
| title_full_unstemmed | Inhibition of Hsp90 in Streptomyces coelicolor |
| title_short | Inhibition of Hsp90 in Streptomyces coelicolor |
| title_sort | inhibition of hsp90 in streptomyces coelicolor |
| topic | Chemistry. |
| url | http://hdl.handle.net/1721.1/36280 |
| work_keys_str_mv | AT wukatherineakatherineann inhibitionofhsp90instreptomycescoelicolor AT wukatherineakatherineann inhibitionofhsp90inscoelicolor |