Alternative transcription start site selection leads to large differences in translation activity in yeast
mRNA levels do not accurately predict protein levels in eukaryotic cells. To investigate contributions of 5′ untranslated regions (5′ UTRs) to mRNA-specific differences in translation, we determined the 5′ UTR boundaries of 96 yeast genes for which in vivo translational efficiency varied by 80-fold....
Main Authors: | Gilbert, Wendy, Rojas Duran, Maria Fernanda |
---|---|
Other Authors: | Massachusetts Institute of Technology. Department of Biology |
Format: | Article |
Language: | en_US |
Published: |
Cold Spring Harbor Laboratory Press
2014
|
Online Access: | http://hdl.handle.net/1721.1/85841 https://orcid.org/0000-0003-2807-9657 |
Similar Items
-
Translation initiation factor eIF4G1 preferentially binds yeast transcript leaders containing conserved oligo-uridine motifs
by: Zinshteyn, Boris, et al.
Published: (2018) -
The ribosomal protein Asc1/RACK1 is required for efficient translation of short mRNAs
by: Gangaramani, Paritosh, et al.
Published: (2016) -
Pseudouridine profiling reveals regulated mRNA pseudouridylation in yeast and human cells
by: Carlile, Thomas M., et al.
Published: (2015) -
Roles for transcript leaders in translation and mRNA decay revealed by transcript leader sequencing
by: Arribere, Joshua Alexander, et al.
Published: (2014) -
Co-transcriptional commitment to alternative splice site selection.
by: Roberts, G, et al.
Published: (1998)