Regulation of HIF: prolyl hydroxylases.

Regulation of HIF: prolyl hydroxylases.

Hypoxia inducible factor (HIF) is an alpha/beta heterodimeric transcriptional complex that plays a key role in directing cellular responses to hypoxia. Recent studies have defined novel oxygen-sensitive signal pathways that regulate the activity of HIF by post-translational hydroxylation at specific...

Podrobná bibliografie
Hlavní autoři:	Stolze, I, Mole, D, Ratcliffe, P
Médium:	Journal article
Jazyk:	English
Vydáno:	2006

Podobné jednotky

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
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Vydáno: (2003)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
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Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
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Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
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The use of dioxygen by HIF prolyl hydroxylase (PHD1).
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Vydáno: (2002)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
Autor: Masson, N, a další
Vydáno: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
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Vydáno: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
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Vydáno: (2019-09-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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Vydáno: (2016)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
Autor: Yeoh, K, a další
Vydáno: (2013)

Iron homeostasis and its interaction with prolyl hydroxylases.
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Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
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Vydáno: (2016-08-01)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
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Vydáno: (2017)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
Autor: Masson, N, a další
Vydáno: (2004)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
Autor: Chowdhury, R, a další
Vydáno: (2013)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
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Vydáno: (2021-01-01)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
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Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
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Vydáno: (2020-07-01)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
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Vydáno: (2006)

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
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Vydáno: (2012)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
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Vydáno: (2019)

Oxygen sensing by HIF hydroxylases.
Autor: Schofield, C, a další
Vydáno: (2004)

Signalling hypoxia by HIF hydroxylases.
Autor: Schofield, C, a další
Vydáno: (2005)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
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Vydáno: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
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Vydáno: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
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Vydáno: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
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Vydáno: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
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Vydáno: (2021-05-01)

The HIF hydroxylase pathway and the tumour microenvironment
Autor: Ratcliffe, P
Vydáno: (2008)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
Autor: Astuti, D, a další
Vydáno: (2011)

Prolyl hydroxylases and therapeutics.
Autor: Smith, T, a další
Vydáno: (2010)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
Autor: Chen, R, a další
Vydáno: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
Autor: Chen, R, a další
Vydáno: (2014)

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
Autor: Andrea Hartner, a další
Vydáno: (2023-06-01)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
Autor: Astuti, D, a další
Vydáno: (2010)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
Autor: Hewitson, K, a další
Vydáno: (2007)

HIF prolyl hydroxylase inhibition protects skeletal muscle from eccentric contraction-induced injury
Autor: Andrew N. Billin, a další
Vydáno: (2018-11-01)

Targeting of HIF-alpha to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation.
Autor: Jaakkola, P, a další
Vydáno: (2001)

Substrate selectivity of prolyl hydroxylases
Autor: McDonough, M
Vydáno: (2018)