Regulation of HIF: prolyl hydroxylases.

Regulation of HIF: prolyl hydroxylases.

Hypoxia inducible factor (HIF) is an alpha/beta heterodimeric transcriptional complex that plays a key role in directing cellular responses to hypoxia. Recent studies have defined novel oxygen-sensitive signal pathways that regulate the activity of HIF by post-translational hydroxylation at specific...

Deskribapen osoa

Xehetasun bibliografikoak
Egile Nagusiak:	Stolze, I, Mole, D, Ratcliffe, P
Formatua:	Journal article
Hizkuntza:	English
Argitaratua:	2006

Antzeko izenburuak

2-oxoglutarate analogue inhibitors of HIF prolyl hydroxylase.
nork: Mole, D, et al.
Argitaratua: (2003)

Determination and comparison of specific activity of the HIF-prolyl hydroxylases.
nork: Tuckerman, JR, et al.
Argitaratua: (2004)

Analogues of dealanylalahopcin are inhibitors of human HIF prolyl hydroxylases.
nork: Schlemminger, I, et al.
Argitaratua: (2003)

Characterization of different isoforms of the HIF prolyl hydroxylase PHD1 generated by alternative initiation.
nork: Tian, Y, et al.
Argitaratua: (2006)

Tuning the transcriptional response to hypoxia by inhibiting HIF prolyl- and asparaginyl-hydroxylases
nork: Chan, M, et al.
Argitaratua: (2016)

The use of dioxygen by HIF prolyl hydroxylase (PHD1).
nork: McNeill, L, et al.
Argitaratua: (2002)

HIF prolyl and asparaginyl hydroxylases in the biological response to intracellular O(2) levels.
nork: Masson, N, et al.
Argitaratua: (2003)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
nork: Cockman, M, et al.
Argitaratua: (2019)

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates
nork: Matthew E Cockman, et al.
Argitaratua: (2019-09-01)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
nork: Chowdhury, R, et al.
Argitaratua: (2016)

Dual-action inhibitors of HIF prolyl hydroxylases that induce binding of a second iron ion.
nork: Yeoh, K, et al.
Argitaratua: (2013)

Iron homeostasis and its interaction with prolyl hydroxylases.
nork: Mole, D
Argitaratua: (2010)

Structural basis for oxygen degradation domain selectivity of the HIF prolyl hydroxylases
nork: Rasheduzzaman Chowdhury, et al.
Argitaratua: (2016-08-01)

Molecular and Cellular Mechanisms of HIF Prolyl Hydroxylase inhibitors in Clinical Trials
nork: Yeh, TL, et al.
Argitaratua: (2017)

The HIF prolyl hydroxylase PHD3 is a potential substrate of the TRiC chaperonin.
nork: Masson, N, et al.
Argitaratua: (2004)

Selective small molecule probes for the hypoxia inducible factor (HIF) prolyl hydroxylases.
nork: Chowdhury, R, et al.
Argitaratua: (2013)

Inhibition of HIF-prolyl hydroxylases improves healing of intestinal anastomoses
nork: Moritz J. Strowitzki, et al.
Argitaratua: (2021-04-01)

HIF Prolyl Hydroxylase Inhibitors for COVID-19 Treatment: Pros and Cons
nork: Andrey A. Poloznikov, et al.
Argitaratua: (2021-01-01)

Tissue expression and functional insights into HIF prolyl hydroxylase domain enzymes
nork: Wijeyekoon, JB
Argitaratua: (2013)

Neuroprotective Effect of HIF Prolyl Hydroxylase Inhibition in an In Vitro Hypoxia Model
nork: Maria Savyuk, et al.
Argitaratua: (2020-07-01)

HIF prolyl hydroxylases in the rat; organ distribution and changes in expression following hypoxia and coronary artery ligation.
nork: Willam, C, et al.
Argitaratua: (2006)

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.
nork: Foxler, D, et al.
Argitaratua: (2012)

Structure–activity relationship and crystallographic studies on 4-hydroxypyrimidine HIF prolyl hydroxylase domain inhibitors
nork: Holt-Martyn, JP, et al.
Argitaratua: (2019)

Oxygen sensing by HIF hydroxylases.
nork: Schofield, C, et al.
Argitaratua: (2004)

Signalling hypoxia by HIF hydroxylases.
nork: Schofield, C, et al.
Argitaratua: (2005)

Structural, biochemical and inhibition studies on hypoxia-inducible factor (HIF) prolyl hydroxylases
nork: Lippl, K
Argitaratua: (2018)

Impact of HIF prolyl hydroxylase inhibitors in heart failure patients with renal anemia
nork: Takahiro Kambara, et al.
Argitaratua: (2024-03-01)

HIF-α Prolyl Hydroxylase Inhibitors and Their Implications for Biomedicine: A Comprehensive Review
nork: Kiichi Hirota
Argitaratua: (2021-04-01)

The HIF-prolyl hydroxylases have distinct and nonredundant roles in colitis-associated cancer
nork: Kilian B. Kennel, et al.
Argitaratua: (2022-11-01)

Network activity in primary hippocampal cultures upon HIF-prolyl hydroxylase inhibition
nork: Savyuk, Maria Olegovna, et al.
Argitaratua: (2021-05-01)

Inhibition of HIF-prolyl 4-hydroxylases as a promising approach to the therapy of cardiometabolic diseases
nork: K A Aitbaev, et al.
Argitaratua: (2018-08-01)

The HIF hydroxylase pathway and the tumour microenvironment
nork: Ratcliffe, P
Argitaratua: (2008)

Mutation analysis of HIF prolyl hydroxylases (PHD/EGLN) in individuals with features of phaeochromocytoma and renal cell carcinoma susceptibility.
nork: Astuti, D, et al.
Argitaratua: (2011)

Prolyl hydroxylases and therapeutics.
nork: Smith, T, et al.
Argitaratua: (2010)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice.
nork: Chen, R, et al.
Argitaratua: (2014)

HIF prolyl hydroxylase inhibition prior to transient focal cerebral ischaemia is neuroprotective in mice
nork: Chen, R, et al.
Argitaratua: (2014)

No benefit of HIF prolyl hydroxylase inhibition for hypertensive renal damage in renovascular hypertensive rats
nork: Andrea Hartner, et al.
Argitaratua: (2023-06-01)

Mutation Analysis of HIF-prolyl hydroxylases (PHD/EGLN) in Inherited Phaeochromocytoma and Renal Cell Carcinoma
nork: Astuti, D, et al.
Argitaratua: (2010)

Epigenetic regulators of neuronal ferroptosis identify novel therapeutics for neurological diseases: HDACs, transglutaminases, and HIF prolyl hydroxylases
nork: Orjon Rroji, et al.
Argitaratua: (2021-01-01)

Hypoxia-inducible factor prolyl-hydroxylase: purification and assays of PHD2.
nork: Hewitson, K, et al.
Argitaratua: (2007)