Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses

Show other versions (1)

A missense C1858T single nucleotide polymorphism within PTPN22 is a strong genetic risk factor for the development of multiple autoimmune diseases. PTPN22 encodes a protein tyrosine phosphatase that negatively regulates immuno-receptor proximal Src and Syk family kinases. Notably, PTPN22 negatively...

Descrición completa

Detalles Bibliográficos
Main Authors:	Sanchez-Blanco, C, Clarke, F, Cornish, G, Depoil, D, Thompson, S, Dai, X, Rawlings, D, Dustin, M, Zamoyska, R, Cope, A, Purvis, H
Formato:	Journal article
Idioma:	English
Publicado:	Elsevier 2018

Títulos similares

Protein tyrosine phosphatase PTPN22 regulates LFA-1 dependent Th1 responses
por: Sanchez-Blanco, C, et al.
Publicado: (2018)

Phosphatase PTPN22 Regulates Dendritic Cell Homeostasis and cDC2 Dependent T Cell Responses
por: Harriet A. Purvis, et al.
Publicado: (2020-03-01)

NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
por: Marianne R. Spalinger, et al.
Publicado: (2023-02-01)

Deletion of the protein tyrosine phosphatase PTPN22 for adoptive T cell therapy facilitates CTL effector function but promotes T cell exhaustion
por: Nicola Logan, et al.
Publicado: (2023-12-01)

Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo
por: Ghaleb Bin Huraib, et al.
Publicado: (2020-01-01)

Dual Role of the PTPN13 Tyrosine Phosphatase in Cancer
por: Soha Mcheik, et al.
Publicado: (2020-12-01)

Association of the protein tyrosine phosphatase non-receptor 22 polymorphism (PTPN22) with endometriosis: a meta-analysis
por: Noel Pabalan, et al.

Autoimmunity-associated allele of tyrosine phosphatase gene PTPN22 enhances anti-viral immunity.
por: Robin C Orozco, et al.
Publicado: (2024-03-01)

Replication of an association between the lymphoid tyrosine phosphatase locus (LYP/PTPN22) with type 1 diabetes, and evidence for its role as a general autoimmunity locus.
por: Smyth, D, et al.
Publicado: (2004)

Autoimmune-associated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue.
por: Fiorillo, E, et al.
Publicado: (2010)

Association of protein tyrosine phosphatase non receptor type 22 (PTPN22) C1858T gene polymorphism with type 1 diabetes mellitus in Egyptian children cohort
por: Ola Elsisi, et al.
Publicado: (2015-09-01)

Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
por: Barr, A, et al.
Publicado: (2006)

Crystal structure of human protein tyrosine phosphatase 14 (PTPN14) at 1.65-A resolution.
por: Barr, A, et al.
Publicado: (2006)

Protein tyrosine phosphatase PTPN1 modulates cell growth and associates with poor outcome in human neuroblastoma
por: Caroline E. Nunes-Xavier, et al.
Publicado: (2019-12-01)

GABAB1e promotes the malignancy of human cancer cells by targeting the tyrosine phosphatase PTPN12
por: Bo Wei, et al.
Publicado: (2021-11-01)

The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
por: Timothy J Bauler, et al.
Publicado: (2008-01-01)

PTPN22 Acts in a Cell Intrinsic Manner to Restrict the Proliferation and Differentiation of T Cells Following Antibody Lymphodepletion
por: Johanna A. Knipper, et al.
Publicado: (2020-01-01)

Reciprocal regulation of C-Maf tyrosine phosphorylation by Tec and Ptpn22.
por: Chih-Chun Liu, et al.
Publicado: (2015-01-01)

Polymorphisms in Protein Tyrosine Phosphatase Non-receptor Type 2 and 22 (PTPN2/22) Are Linked to Hyper-Proliferative T-Cells and Susceptibility to Mycobacteria in Rheumatoid Arthritis
por: Robert C. Sharp, et al.
Publicado: (2018-01-01)

Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
por: Eswaran, J, et al.
Publicado: (2006)

Autoimmunity linked protein phosphatase PTPN22 as a target for cancer immunotherapy
por: Jeanne Cheung, et al.
Publicado: (2020-10-01)

Mutation analysis of the tyrosine phosphatase PTPN2 in Hodgkin’s lymphoma and T-cell non-Hodgkin’s lymphoma
por: Maria Kleppe, et al.
Publicado: (2011-11-01)

Tyrosine phosphatase PTPN11/SHP2 in solid tumors - bull’s eye for targeted therapy?
por: Xun Chen, et al.
Publicado: (2024-03-01)

Modulation of TCR Signaling by Tyrosine Phosphatases: From Autoimmunity to Immunotherapy
por: Patricia Castro-Sanchez, et al.
Publicado: (2020-12-01)

pTyr421 cortactin is overexpressed in colon cancer and is dephosphorylated by curcumin: involvement of non-receptor type 1 protein tyrosine phosphatase (PTPN1).
por: Vijayababu M Radhakrishnan, et al.
Publicado: (2014-01-01)

Molecular basis of the interaction of the human tyrosine phosphatase PTPN3 with the hepatitis B virus core protein
por: Mariano Genera, et al.
Publicado: (2021-01-01)

LFA-1 in T cell priming, differentiation, and effector functions
por: Gerard, A, et al.
Publicado: (2021)

Interactions of the protein tyrosine phosphatase PTPN3 with viral and cellular partners through its PDZ domain: insights into structural determinants and phosphatase activity
por: Mariano Genera, et al.
Publicado: (2023-05-01)

An In Silico Study Investigating Camptothecin-Analog Interaction with Human Protein Tyrosine Phosphatase, SHP2 (PTPN11)
por: Donald Bajia, et al.
Publicado: (2023-06-01)

The lymphocyte function-associated LFA-1, CD2, and LFA-3 molecules: cell adhesion receptors of the immune system.
por: Springer, T, et al.
Publicado: (1987)

Genetic variations of PTPN2 and PTPN22: Role in the Pathogenesis of Type 1 Diabetes and Crohn’s Disease
por: Muna eAbdulrahim, et al.
Publicado: (2015-12-01)

Crispr/Cas Mediated Deletion of PTPN22 in Jurkat T Cells Enhances TCR Signaling and Production of IL-2
por: Cara Bray, et al.
Publicado: (2018-11-01)

Tyrosine Phosphatases in the HER2-Directed Motility of Ovarian Cancer Cells: Involvement of PTPN12, ERK5 and FAK
por: Emma Villa-Moruzzi
Publicado: (2011-01-01)

Protein tyrosine phosphatase nonreceptor 13 (PTPN13) is targeted by human papillomavirus 16 E6 in cervical epithelium
por: Bossler A, et al.
Publicado: (2009-06-01)

The arrangement of the immunoglobulin-like domains of ICAM-1 and the binding sites for LFA-1 and rhinovirus.
por: Staunton, D, et al.
Publicado: (1990)

Androgens contribute to sex bias of autoimmunity in mice by T cell-intrinsic regulation of Ptpn22 phosphatase expression
por: Jean Lee, et al.
Publicado: (2024-09-01)

Two-way signalling through the LFA-1 lymphocyte adhesion receptor.
por: Dustin, M
Publicado: (1990)

Redoxing PTPN22 activity
por: Magdalena Shumanska, et al.
Publicado: (2022-05-01)

On the species specificity of the interaction of LFA-1 with intercellular adhesion molecules.
por: Johnston, S, et al.
Publicado: (1990)

Small GTPases and LFA-1 reciprocally modulate adhesion and signaling.
por: Mor, A, et al.
Publicado: (2007)