Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides †

Rhodanine derived enethiols react to give 1,3-dithiolanes and mixed disulfides †

Rhodanines have been characterised as ‘difficult to progress’ compounds for medicinal use, though one rhodanine is used for diabetes mellitus treatment and others are in clinical development. Rhodanines can undergo hydrolysis to enethiols which are inhibitors of metallo-enzymes, such as metallo β-la...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Kamps, JJAG, Zhang, D, Claridge, TDW, Schofield, CJ
Format:	Journal article
Język:	English
Wydane:	Royal Society of Chemistry 2024

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