Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

Endothelial cell tetrahydrobiopterin deficiency attenuates LPS-induced vascular dysfunction and hypotension

Overproduction of nitric oxide (NO) is thought to be a key mediator of the vascular dysfunction and severe hypotension in patients with endotoxaemia and septic shock. The contribution of NO produced directly in the vasculature by endothelial cells to the hypotension seen in these conditions, vs. the...

Полное описание

Библиографические подробности
Главные авторы:	Chuaiphichai, S, Starr, A, Nandi, M, Channon, K, McNeill, E
Формат:	Journal article
Язык:	English
Опубликовано:	Elsevier 2015

Схожие документы

A key role for tetrahydrobiopterin-dependent endothelial NOS regulation in vascular resistance arteries: studies in endothelial cell tetrahydrobiopterin-deficient mice
по: Chuaiphichai, S, и др.
Опубликовано: (2017)

Endothelial cell vasodilator dysfunction mediates progressive pregnancy-induced hypertension in endothelial cell tetrahydrobiopterin deficient mice.
по: Chuaiphichai, S, и др.
Опубликовано: (2023)

Deficiency in endothelial cell tetrahydrobiopterin increases resistance vascular remodelling, blood pressure, and susceptibility to aortic abdominal aneurysm in response to angiotensin II
по: Chuaiphichai, S, и др.
Опубликовано: (2018)

Endothelial cell tetrahydrobiopterin modulates sensitivity to Ang (Angiotensin) II–induced vascular remodeling, blood pressure, and abdominal aortic aneurysm
по: Chuaiphichai, S, и др.
Опубликовано: (2018)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
по: Chuaiphichai, S, и др.
Опубликовано: (2014)

Cell-autonomous role of endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation
по: Chuaiphichai, S, и др.
Опубликовано: (2014)

Conditional knockout of GCH1 in leukocytes and endothelial cells: A novel model to study tetrahydrobiopterin-dependent NOS functions in vivo
по: McNeill, E, и др.
Опубликовано: (2012)

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression
по: Douglas, G, и др.
Опубликовано: (2018)

The requirement for endothelial cell tetrahydrobiopterin in health and disease
по: Chuaiphichai, S
Опубликовано: (2014)

The role of tetrahydrobiopterin in inflammation and cardiovascular disease.
по: McNeill, E, и др.
Опубликовано: (2012)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease.
по: Crabtree, M, и др.
Опубликовано: (2011)

Synthesis and recycling of tetrahydrobiopterin in endothelial function and vascular disease
по: Crabtree, M, и др.
Опубликовано: (2011)

Tetrahydrobiopterin determines vascular remodeling through enhanced endothelial cell survival and regeneration.
по: Ali, Z, и др.
Опубликовано: (2013)

Tetrahydrobiopterin: a vascular redox target to improve endothelial function.
по: Channon, K
Опубликовано: (2012)

Tetrahydrobiopterin: regulator of endothelial nitric oxide synthase in vascular disease.
по: Channon, K
Опубликовано: (2004)

CCR2-mediated antiinflammatory effects of endothelial tetrahydrobiopterin inhibit vascular injury-induced accelerated atherosclerosis.
по: Ali, Z, и др.
Опубликовано: (2008)

Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease.
по: Alp, N, и др.
Опубликовано: (2004)

303A cell-Autonomous role for endothelial GTP cyclohydrolase 1 and tetrahydrobiopterin in blood pressure regulation.
по: Chuaiphichai, S, и др.
Опубликовано: (2014)

201 Regulation of INOS Function, Redox State and NRF2 Activation by Macrophage GCH1 and Tetrahydrobiopterin.
по: McNeill, E, и др.
Опубликовано: (2014)

Tetrahydrobiopterin in cardiovascular health and disease.
по: Bendall, J, и др.
Опубликовано: (2014)

Regulation of endothelial nitric oxide synthase (eNOS) by tetrahydrobiopterin in vascular disease
по: Alp, N, и др.
Опубликовано: (2004)

Endothelial tetrahydrobiopterin deficiency accelerates atherosclerotic progression by nitric oxide synthase uncoupling
по: Khoo, J, и др.
Опубликовано: (2005)

Tetrahydrobiopterin and Endothelial Dysfunction in Cardiovascular Diseases
по: Shinozaki Kazuya, и др.
Опубликовано: (2006-02-01)

Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice.
по: Schmidt, T, и др.
Опубликовано: (2010)

Increased endothelial tetrahydrobiopterin levels by GTPCH over expression in transgenic mice prevents diabetic endothelial dysfunction
по: Alp, N, и др.
Опубликовано: (2003)

Endothelial GTP cyclohydrolase and tetrahydrobiopterin regulate gestational blood pressure, uteroplacental remodeling and fetal growth
по: Chuaiphichai, S, и др.
Опубликовано: (2021)

Endothelial cell tetrahydrobiopterin: going with the flow.
по: De Bono, J, и др.
Опубликовано: (2007)

Tetrahydrobiopterin deficiency increases susceptibility to atherosclerosis
по: Khoo, J, и др.
Опубликовано: (2005)

Tetrahydrobiopterin (BH4) Improves Endothelial Cell Survival After Vascular Injury
по: Rinze, R, и др.
Опубликовано: (2008)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency.
по: Crabtree, M, и др.
Опубликовано: (2011)

Dihydrofolate reductase protects endothelial nitric oxide synthase from uncoupling in tetrahydrobiopterin deficiency
по: Crabtree, M, и др.
Опубликовано: (2011)

Chronic treatment with tetrahydrobiopterin reverses endothelial dysfunction and oxidative stress in hypercholesterolaemia.
по: Cosentino, F, и др.
Опубликовано: (2008)

Regulation of eNOS function by tetrahydrobiopterin in vascular disease
по: Channon, K
Опубликовано: (2004)

Regulation of iNOS function and cellular redox state by macrophage Gch1 reveals specific requirements for tetrahydrobiopterin in NRF2 activation.
по: McNeill, E, и др.
Опубликовано: (2015)

Endothelial nitric oxide synthase dysfunction in diabetic mice: importance of tetrahydrobiopterin in eNOS dimerisation.
по: Cai, S, и др.
Опубликовано: (2005)

Novel role of 5-methyl-(6S)-tetrahydrofolate in mediating endothelial cell tetrahydrobiopterin in pregnancy and implications for gestational hypertension
по: Dickinson, Y, и др.
Опубликовано: (2024)

Induction of vascular GTP-cyclohydrolase I and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis.
по: Antoniades, C, и др.
Опубликовано: (2011)

Induction of vascular GTP-cyclohydrolase i and endogenous tetrahydrobiopterin synthesis protect against inflammation-induced endothelial dysfunction in human atherosclerosis
по: Antoniades, C, и др.
Опубликовано: (2011)

Hydrogen Peroxide Stimulates the LPS-induced Tetrahydrobiopterin Synthesis in Mouse Brain Microvascular Endothelial Cells
по: Shiota Kazuhiro, и др.
Опубликовано: (2002-02-01)

Low-dose Tetrahydrobiopterin Supplementation Reduces Atherosclerosis Progression in Apolipoprotein E-Knockout Mice via Effects on Vascular T cell Infiltration
по: Schmidt, T, и др.
Опубликовано: (2009)