Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases

Assessing the contribution of rare protein-coding germline variants to prostate cancer risk and severity in 37,184 cases

To assess the contribution of rare coding germline genetic variants to prostate cancer risk and severity, we perform here a meta-analysis of 37,184 prostate cancer cases and 331,329 male controls from five cohorts with germline whole exome or genome sequencing data, and one cohort with imputed array...

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Autors principals: Mitchell, J, Camacho, N, Shea, P, Stopsack, KH, Joseph, V, Burren, OS, Dhindsa, RS, Nag, A, Berchuck, JE, O’Neill, A, Abbasi, A, Zoghbi, AW, Alegre-Díaz, J, Kuri-Morales, P, Berumen, J, Tapia-Conyer, R, Emberson, J, Torres, JM, Collins, R, Wang, Q, Goldstein, D, Matakidou, A, Haefliger, C, Anderson-Dring, L
Format: Journal article
Idioma:English
Publicat: Nature Research 2025

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