Distinctive binding properties of human monoclonal LGI1 autoantibodies determine pathogenic mechanisms
Autoantibodies against leucine-rich glioma inactivated 1 (LGI1) are found in patients with limbic encephalitis and focal seizures. Here, we generate patient-derived monoclonal antibodies (mAbs) against LGI1. We explore their sequences and binding characteristics, plus their pathogenic potential usin...
Հիմնական հեղինակներ: | , , , , , , , , , , , , , , , , , , , , , , , , |
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Ձևաչափ: | Journal article |
Լեզու: | English |
Հրապարակվել է: |
Oxford University Press
2020
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