Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

Glucokinase (GCK) serves as the pancreatic glucose sensor. Heterozygous inactivating GCK mutations cause hyperglycemia, whereas activating mutations cause hypoglycemia. We studied the GCK V62M mutation identified in two families and co-segregating with hyperglycemia to understand how this mutation r...

תיאור מלא

מידע ביבליוגרפי
Main Authors:	Gloyn, A, Odili, S, Zelent, D, Buettger, C, Castleden, H, Steele, A, Stride, A, Shiota, C, Magnuson, M, Lorini, R, d'Annunzio, G, Stanley, C, Kwagh, J, van Schaftingen, E, Veiga-da-Cunha, M, Barbetti, F, Dunten, P, Han, Y, Grimsby, J, Taub, R, Ellard, S, Hattersley, A, Matschinsky, F
פורמט:	Journal article
שפה:	English
יצא לאור:	2005

Insights into the structure and regulation of glucokinase from a novel mutation (V62M), which causes maturity-onset diabetes of the young.

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