Out of balance: R-loops in human disease

Out of balance: R-loops in human disease

R-loops are cellular structures composed of an RNA/DNA hybrid, which is formed when the RNA hybridises to a complementary DNA strand and a displaced single-stranded DNA. R-loops have been detected in various organisms from bacteria to mammals and play crucial roles in regulating gene expression, DNA...

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Bibliografiske detaljer
Main Authors:	Groh, M, Gromak, N
Format:	Journal article
Sprog:	English
Udgivet:	Public Library of Science 2014

Lignende værker

Out of balance: R-loops in human disease.
af: Matthias Groh, et al.
Udgivet: (2014-09-01)

R-loop immunoprecipitation: a method to detect R-loop interacting factors
af: Beghè, C, et al.
Udgivet: (2022)

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome
af: Groh, M, et al.
Udgivet: (2014)

RNA/DNA hybrid interactome identifies DXH9 as a molecular player in transcriptional termination and R-loop-associated DNA damage
af: Cristini, A, et al.
Udgivet: (2018)

SOSS-INTAC: a new gatekeeper of genomic integrity at the interface of transcription and R-loops
af: Gromak, N
Udgivet: (2023)

RNA/DNA Hybrid Interactome Identifies DXH9 as a Molecular Player in Transcriptional Termination and R-Loop-Associated DNA Damage
af: Agnese Cristini, et al.
Udgivet: (2018-05-01)

R-loops associated with triplet repeat expansions promote gene silencing in Friedreich ataxia and fragile X syndrome.
af: Matthias Groh, et al.
Udgivet: (2014-05-01)

The role of R-loops in the pathology of trinucleotide expansion diseases
af: Groh, M
Udgivet: (2015)

Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops
af: Ma, TS, et al.
Udgivet: (2023)

APOBEC3B regulates R-loops and promotes transcription-associated mutagenesis in cancer
af: McCann, JL, et al.
Udgivet: (2023)

The intrinsic ability of double-stranded DNA to carry out D-loop and R-loop formation
af: Takehiko Shibata, et al.
Udgivet: (2020-01-01)

Mechanisms of transcriptional dysregulation in repeat expansion disorders.
af: Groh, M, et al.
Udgivet: (2014)

Mechanisms underlining R-loop biology and implications for human disease
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Udgivet: (2025-02-01)

Out of Balance
af: Douglas McCormick
Udgivet: (2008-03-01)

Senataxin: genome guardian at the interface of transcription and neurodegeneration
af: Groh, M, et al.
Udgivet: (2016)

Transcription-dependent DNA double-strand breaks and human disease
af: Cristini, A, et al.
Udgivet: (2020)

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
af: Cristini, A, et al.
Udgivet: (2022)

Dual processing of R-loops and topoisomerase I induces transcription-dependent DNA double-strand breaks
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Udgivet: (2019)

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Udgivet: (2017)

Transcription-dependent DNA double-strand breaks and human disease
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Udgivet: (2020-03-01)

R-loop and diseases: the cell cycle matters
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Udgivet: (2024-04-01)

Integrating out new fermions at one loop
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Udgivet: (2021-01-01)

Dual Processing of R-Loops and Topoisomerase I Induces Transcription-Dependent DNA Double-Strand Breaks
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Udgivet: (2019-09-01)

AutoGAN: An Automated Human-Out-of-the-Loop Approach for Training Generative Adversarial Networks
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Udgivet: (2023-02-01)

RNase H2, mutated in Aicardi‐Goutières syndrome, resolves co-transcriptional R-loops to prevent DNA breaks and inflammation
af: Agnese Cristini, et al.
Udgivet: (2022-05-01)

Autopilot, Mind Wandering, and the Out of the Loop Performance Problem
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Udgivet: (2017-10-01)

Effects of initial eye position on saccades evoked by microstimulation in the primate superior colliculus: implications for models of the SC read-out process
af: Jennifer M Groh, et al.
Udgivet: (2011-01-01)

Human immunodeficiency virus-1 induces host genomic R-loops and preferentially integrates its genome near the R-loop regions
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Udgivet: (2024-12-01)

Comparison of Balance and Out of Balance Main Battle Tank Armaments
af: David J. Purdy
Udgivet: (2001-01-01)

Acid-Base Balance (Out of Print)
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Udgivet: (2006-11-01)

Human 5' --> 3' exonuclease Xrn2 promotes transcription termination at co-transcriptional cleavage sites.
af: West, S, et al.
Udgivet: (2004)

Hardware-In-the-Loop Equipment for the Development of an Automatic Perturbator for Clinical Evaluation of Human Balance Control
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Udgivet: (2020-12-01)

Global balance and the environment - Development feedback loop
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Udgivet: (2019-01-01)

R-loop landscape in mature human sperm: Regulatory and evolutionary implications
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Udgivet: (2023-04-01)

Hybrid Open-Loop Closed-Loop Control of Coupled Human–Robot Balance During Assisted Stance Transition With Extra Robotic Legs
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Reflexivity 3. Breaking out the Reflexive Loop to Decolonise Practice
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Udgivet: (2023-12-01)

Looping out loud: A multimodal analysis of humour on Vine
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Udgivet: (2017-01-01)

Natural products in a world out-of-balance
af: Geoffrey A. Cordell, et al.
Udgivet: (2006-09-01)