Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

Phosphodiesterases maintain signaling fidelity via compartmentalization of cyclic nucleotides.

Novel technological advances have improved our understanding of how cyclic nucleotides are able to convey signals faithfully between cellular compartments. Phosphodiesterases play a crucial role in shaping these signals in health and disease. The concept of compartmentalization is guiding the search...

Полное описание

Библиографические подробности
Главные авторы:	Lomas, O, Zaccolo, M
Формат:	Journal article
Язык:	English
Опубликовано:	American Physiological Society 2014

Схожие документы

Modulation of compartmentalized cyclic nucleotide signalling via local inhibition of phosphodiesterase activity
по: Brescia, M, и др.
Опубликовано: (2016)

Phosphodiesterases and compartmentalized cAMP signalling in the heart.
по: Zaccolo, M
Опубликовано: (2006)

Phosphodiesterases and subcellular compartmentalized cAMP signaling in the cardiovascular system.
по: Stangherlin, A, и др.
Опубликовано: (2012)

Cyclic nucleotide phosphodiesterases in health and disease /
по: Beavo, Joe, и др.
Опубликовано: (2007)

Editorial: Cyclic nucleotide phosphodiesterases (PDEs) signaling in the endocrine system
по: Federica Campolo, и др.
Опубликовано: (2025-01-01)

Cyclic nucleotide specific phosphodiesterases of <it>Leishmania major</it>
по: Linder Markus, и др.
Опубликовано: (2006-03-01)

The role of cyclic nucleotide phosphodiesterases in the regulation of adipocyte lipolysis
по: Peter B. Snyder, и др.
Опубликовано: (2005-03-01)

Review: Modulation of striatal neuron activity by cyclic nucleotide signaling and phosphodiesterase inhibition.
по: Threlfell, S, и др.
Опубликовано: (2013)

Regulation of the renin-angiotensin-aldosterone system by cyclic nucleotides and phosphodiesterases
по: Stepan Gambaryan, и др.
Опубликовано: (2023-08-01)

Role of Cyclic Nucleotide Phosphodiesterases in Inner Ear and Hearing
по: Rahul Mittal, и др.
Опубликовано: (2017-11-01)

AMPK antagonizes hepatic glucagon-stimulated cyclic AMP signalling via phosphorylation-induced activation of cyclic nucleotide phosphodiesterase 4B
по: M. Johanns, и др.
Опубликовано: (2016-03-01)

Editorial: Cyclic Nucleotide Phosphodiesterases (PDEs) in Immune Regulation and Inflammation
по: Stefan Brocke, и др.
Опубликовано: (2022-07-01)

Apicomplexan phosphodiesterases in cyclic nucleotide turnover: conservation, function, and therapeutic potential
по: William J. Moss, и др.
Опубликовано: (2024-02-01)

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.
по: Miller, C, и др.
Опубликовано: (2011)

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart
по: Miller, C, и др.
Опубликовано: (2011)

Compartmentalized phosphodiesterase-2 activity blunts beta-adrenergic cardiac inotropy via an NO/cGMP-dependent pathway.
по: Mongillo, M, и др.
Опубликовано: (2006)

Expression and regulation of cyclic nucleotide phosphodiesterases in human and rat pancreatic islets.
по: Emilia Heimann, и др.
Опубликовано: (2010-01-01)

Local termination of 3'-5'-cyclic adenosine monophosphate signals: the role of A kinase anchoring protein-tethered phosphodiesterases.
по: Stangherlin, A, и др.
Опубликовано: (2011)

Pre-synaptic sympathetic calcium channels, cyclic nucleotide-coupled phosphodiesterases and cardiac excitability
по: Li, D, и др.
Опубликовано: (2019)

2',3'-cyclic nucleotide 3'-phosphodiesterases inhibit hepatitis B virus replication.
по: Hui Ma, и др.
Опубликовано: (2013-01-01)

Identification and Localization of the Cyclic Nucleotide Phosphodiesterase 10A in Bovine Testis and Mature Spermatozoa.
по: Serge Goupil, и др.
Опубликовано: (2016-01-01)

Cyclic Nucleotide-Specific Optogenetics Highlights Compartmentalization of the Sperm Flagellum into cAMP Microdomains
по: Diana N. Raju, и др.
Опубликовано: (2019-06-01)

Investigation of an 18F-labelled Imidazopyridotriazine for Molecular Imaging of Cyclic Nucleotide Phosphodiesterase 2A
по: Susann Schröder, и др.
Опубликовано: (2018-03-01)

Mechanisms of cyclic nucleotide phosphodiesterases in modulating T cell responses in murine graft-versus-host disease.
по: Michael Weber, и др.
Опубликовано: (2013-01-01)

A complex phosphodiesterase system controls β-adrenoceptor signalling in cardiomyocytes
по: Mongillo, M, и др.
Опубликовано: (2006)

A complex phosphodiesterase system controls beta-adrenoceptor signalling in cardiomyocytes.
по: Mongillo, M, и др.
Опубликовано: (2006)

Functional regulatory T cells produced by inhibiting cyclic nucleotide phosphodiesterase type 3 prevent allograft rejection.
по: Feng, G, и др.
Опубликовано: (2011)

Novel Radioligands for Cyclic Nucleotide Phosphodiesterase Imaging with Positron Emission Tomography: An Update on Developments Since 2012
по: Susann Schröder, и др.
Опубликовано: (2016-05-01)

Myelin 2',3'-cyclic nucleotide 3'-phosphodiesterase: active-site ligand binding and molecular conformation.
по: Matti Myllykoski, и др.
Опубликовано: (2012-01-01)

PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases.
по: Terrin, A, и др.
Опубликовано: (2006)

Compartmentalized cAMP/PKA signalling regulates cardiac excitation-contraction coupling.
по: Lissandron, V, и др.
Опубликовано: (2006)

The single cyclic nucleotide-specific phosphodiesterase of the intestinal parasite Giardia lamblia represents a potential drug target.
по: Stefan Kunz, и др.
Опубликовано: (2017-09-01)

Cyclic nucleotide signalling in malaria parasites
по: David A. Baker, и др.
Опубликовано: (2017-01-01)

PDE-Mediated Cyclic Nucleotide Compartmentation in Vascular Smooth Muscle Cells: From Basic to a Clinical Perspective
по: Margarida Lorigo, и др.
Опубликовано: (2021-12-01)

cAMP and cGMP signaling cross-talk: role of phosphodiesterases and implications for cardiac pathophysiology.
по: Zaccolo, M, и др.
Опубликовано: (2007)

Phenotypic, chemical and functional characterization of cyclic nucleotide phosphodiesterase 4 (PDE4) as a potential anthelmintic drug target.
по: Thavy Long, и др.
Опубликовано: (2017-07-01)

Local modulation of cystic fibrosis conductance regulator: cytoskeleton and compartmentalized cAMP signalling.
по: Monterisi, S, и др.
Опубликовано: (2013)

Catalysis and regulation of cyclic dinucleotide specific phosphodiesterases
по: Rao, Feng
Опубликовано: (2011)

Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.
по: Mohamed, T, и др.
Опубликовано: (2011)

Compartmentalization – A Prerequisite for Maintaining and Changing an Identity
по: Philipp Rottmann, и др.
Опубликовано: (2016-06-01)